The contributing genes to this pathway, e.g. CCKBR, CHRM5, EDNRA, LPAR1, SSTR2/3, and SCTR, have diverse functions in regulating the endocrine and exocrine functions of the pancreas, which are highly relevant to pancreatic cancer [32], [33], [34], [35]. This evidence concerns the gene EDNRA and familial pancreatic carcinoma.