Two specific macrophage subpopulations are at the forefront: F4/80+/CD11b+/CD11c+, M1-like macrophages indicating proinflammatory responses in diet induced obesity (DIO); and, F4/80+/CD11b+/CD11c−, M2-like macrophages which maintain homeostasis by suppressing proinflammatory signals [10], [11], [12]. Here, ITGAM is linked to obesity due to melanocortin 4 receptor deficiency.