A state of low-grade inflammation in obesity is associated with disturbances of adipose tissue-derived signaling molecules including adipokines such as acylation stimulating protein (ASP), adiponectin, leptin, as well as various cytokines/chemokines including interleukin-6 (IL-6), monocyte chemotactic protein-1 (MCP-1), Granulocyte colony-stimulating factor (G-CSF), keratinocyte-derived chemokine (KC) and Rantes [1], [2], [3], [4], [5], [6]. This evidence concerns the gene IL6 and obesity due to melanocortin 4 receptor deficiency.