HAPLN1 and melanoma: Figure 4 shows the 2-D overlapping image of A375 and HEMa-LP exosome protein expression. Selected proteins have been identified and are listed in Table 2. Among the identified proteins were annexin A1, annexin A2, syntenin-1, and hyaluronan and proteoglycan link protein 1 (HAPLN1), which all have functions related to angiogenesis, melanoma cell invasion, migration, and metastasis [23], [31], [34], [35].