Since preclinical studies in rodents signaled that diets deficient in n–3 PUFAs lead to lower striatal VMAT2 density by 25 to 60% and reduce stimulant-induced DA release [10] we were interested in evaluating the potential of n–3 PUFA as means to increase VMAT2 availability, enhance DA storage and release, and prevent relapse in cocaine addicts. Here, SLC18A2 is linked to cocaine dependence.