ING4 and malignant colon neoplasm: Gene deletion or reduced expression of ING4 has been reported in various cancers including glioma, breast cancer, head and neck carcinoma, melanoma, hepatocellular carcinoma, gastric carcinoma, colon cancer, and lung cancer, implicating a tumor suppressive role of ING4 in diverse tissue types [20], [23], [25]–[32].