Moreover, miR-20a has been shown to targets E2F1 and prevents apoptosis of the PC3 prostate cancer cell line [46] whose tumorigenicity has been independently shown to be dependent on Ets2 transcription factor [56] while another prostate cell line is also characterized by Ets2 over expression and Hbp1 down regulation [41]. Here, E2F1 is linked to Familial prostate cancer.