Mutation on Ser172 β-tubulin leads to defects in microtubule dynamics and cell division in yeast [50], phosphorylation by Cdk1 kinase inhibits tubulin dimer addition to microtubules in vitro[51] and phosphorylation on Ser165 α6 tubulin by PKCα leads to microtubule elongation and motility in human breast cancer cells [52]. This evidence concerns the gene PRKCA and breast cancer.