In this study, EGCG-mediated LMP was clearly demonstrated via evident lysosomal dilation (increased cytosolic vacuolization, Figure 2), cytosolic translocation of lysosomal enzyme cathepsins (Figure 5B), increase of lysosomal pH (by LTR staining, Figure 5A), and increased cytosolic acidification (by AO staining, Figure 5C), eventually leading to non-apoptotic cell death in human cancer cells. Here, CTSS is linked to cancer.