Using wild type (WT) and MOD-1 mice, we determined the effects of iso-caloric HF diets formulated with casein (CAS) as a control protein, or soy protein isolate (SPI) on body weight, adiposity, serum concentrations of insulin and adipocytokines, liver and adipose tissue morphology, and expression of lipogenic, proliferation-associated, and adipocytokine genes. Here, INS is linked to hydrops fetalis.