To identify the paracrine factors responsible for T47D carcinoma cell growth stimulation we treated the co-cultures with neutralizing antibodies to eleven factors implicated in stroma-carcinoma interactions (FGF-2, HB-EGF, Heparanase-1, HGF, IGF-1, IGF-2, MT1-MMP, PDGF, SDF-1, TGF-β1, and Wnt-1). This evidence concerns the gene HPSE and carcinoma.