Atrial septal defect (Q21.1), axial skeletal malformations (Q67.5; Q76.0–Q76.8), severe ear malformation (Q16.0 and Q17.2), and ventricular septal defect (Q21.0) showed a strong association with insulin exposure using SICK and OECA approaches. The gene discussed is INS; the disease is atrial septal defect.