To determine if caspase-dependent apoptosis was involved in the E1A-mediated sensitisation in prostate cancer cells, cells were infected with AdE1A12S mutants and treated with mitoxantrone under synergistic conditions with and without the addition of the pan-caspase inhibitor v-ZAD-fmk (Fig. 3B). This evidence concerns the gene DHTKD1 and prostate carcinoma.