Consistent with that result, and with our prediction that IL-1β induces acute weight loss after rVSV infection, ASC−/− (n = 5) mice lost slightly less weight after rVSV challenge than did wild type C57BL/6 (n = 6) mice infected in parallel, with the difference only reaching statistical significance only on the second day after challenge (P = 0.004, Mann Whitney Test, Figure 4B). Here, IL1B is linked to infection.