Also, there are reports that rapid IL-17 production by γδ T cells independent of differentiation through the previously noted Th17 cells, with these cells shown as the dominant IL-17 producers in multiple murine infection models [22] These data suggest an early role for γδ T-cell mediation in murine sepsis, the effects of which likely occur before Th17 effector cell differentiation. This evidence concerns the gene IL17A and Sepsis.