Jo et al. have demonstrated that a combination therapy with anti-VEGF and anti-PDGFR is more effective for CNV prevention and regression [46].Nevertheless, in a model of injury-induced choroidal neovascularization, a VEGF inhibitor decreases CNV but administration of a PDGF inhibitor does not decrease CNV [47]. This evidence concerns the gene PDGFRB and choroidal neovascularization.