For example, an GWAS conduced in Norwegian by using Illumina's HumanHap550 genotyping Bead Chip reported that the SNP rs1051730 of CHRNA3 was significantly associated with COPD risk (P = 5.74×10−10) [11], and another study conducted in American reported that the SNP rs8042374 in 15 q25 was susceptibility loci for lung cancer (P = 7.75×10−12) [16]. The gene discussed is CHRNA3; the disease is lung cancer.