Two aberrations, both of them identified in fetuses with CHD, overlap with previously reported alterations associated with developmental anomalies and are likely the underlying genetic cause [38]–[40]: 1) A 363 kb de novo deletion in 16q24.1, encompassing five genes (FOXF1, FOXC2, MTHFSD, FLJ30679 and FOXL1), was detected in a fetus with left heart hypoplasia (case 2); 2) the recurrent 2.2 Mb 15q13.3 deletion was identified in a fetus with right heart hypoplasia as well as in the healthy mother (case 1). This evidence concerns the gene MTHFSD and coronary artery disorder.