Indeed we have shown that out of the endothelial enriched genes, Smurf2, Hex-B, Atf1, and Nras, plus Rrm2, which has known roles in tumour biology, that depletion of Rrm2, Atf1 and Hex-B have anti-angiogenic consequences in ex vivo mouse aortic ring assays. Here, RRM2 is linked to neoplasm.