It has been shown that miR-375 suppresses Ras dexamethasone-induced 1 (RASD1) as its potential target, and RASD1 can suppress the growth of breast cancer cells and down-regulate ERα expression (Vaidyanathan et al., 2004; de Souza Rocha Simonini et al., 2010). The gene discussed is RASD1; the disease is breast carcinoma.