Whether caused by a gain or loss of function of CAPN5, it is likely that the further elucidation of the pathogenic mechanism of ADNIV will provide important new insight into some of the most important causes of irreversible human blindness: autoimmune uveitis, retinitis pigmentosa, proliferative vitreoretinopathy and diabetic retinopathy. The gene discussed is CAPN5; the disease is Blindness.