Infection of susceptible mouse strains that carry a mutation in the gene encoding for a metal transporter present on the SCV membrane named Nramp1 (Slc11a1), such as CL57/BL6 or BALB/C mice, produces a disease that resembles typhoid fever upon inoculation with S. Typhimurium [20]. Here, SLC11A1 is linked to typhoid fever.