HMGB1 and rhegmatogenous retinal detachment: To address mechanisms involved in the pathogenesis of proliferative vitreoretinal disorders and to identify molecular targets for treatment and/or preventive intervention, we measured the levels of OPN, HMGB1, CTGF, and PEDF in the vitreous fluid from patients with PDR, PVR, and rhegmatogenous retinal detachment with no PVR (RD).