To address mechanisms involved in the pathogenesis of proliferative vitreoretinal disorders and to identify molecular targets for treatment and/or preventive intervention, we measured the levels of OPN, HMGB1, CTGF, and PEDF in the vitreous fluid from patients with PDR, PVR, and rhegmatogenous retinal detachment with no PVR (RD). Here, CCN2 is linked to rhegmatogenous retinal detachment.