Therefore, our aim was to assess the serum levels of E-cadherin, EMMPRIN and their potential regulators (MMP-8, MMP-7, TIMP-1, TIMP-2) in children with CKD, on peritoneal dialysis and on hemodialysis, searching for the differences between those modalities and their potential applicability as novel indexes of apoptosis. The gene discussed is TIMP2; the disease is chronic kidney disease.