Therefore, our aim was to assess the serum levels of E-cadherin, EMMPRIN and their potential regulators (MMP-8, MMP-7, TIMP-1, TIMP-2) in children with CKD, on peritoneal dialysis and on hemodialysis, searching for the differences between those modalities and their potential applicability as novel indexes of apoptosis. This evidence concerns the gene CDH1 and chronic kidney disease.