PTEN and breast cancer: Studies have demonstrated that miR-21 functions as an oncogene by targeting tumor suppressor genes including tropomyosin 1 (TPM1), programmed cell death 4 (PDCD4), and phosphatase and tensin homolog (PTEN), leading to cell proliferation and inhibition of apoptosis and regulating cancer invasion and metastasis in breast cancer (Zhu et al. 2007; Frankel et al. 2008; Yan et al. 2008).