WNT1 and breast cancer: For example, a recent publication from our laboratory6 describes the development and characterization of a transplant model of claudin-low and basal-like mammary cancers, which overcomes many existing limitations of xenograft models by using (1) cells derived from a spontaneous MMTV-Wnt-1 mouse mammary tumor that, like basal-like breast cancers in women, are responsive to obesity-related signals,50,51 and (2) a wild-type, syngeneic host with normal immune function, mammary gland development, and metabolic responses to energy balance modulation.