AKT1 and obesity due to melanocortin 4 receptor deficiency: Accordingly, drugs that perturb IPMK signaling actions on major metabolic signaling targets, such as Akt, mTOR, and AMPK, may have therapeutic applications for metabolic syndromes (e.g., obesity, type 2 diabetes) and related eating disorders, such as bulimia and anorexia nervosa.