SIRT1 and neoplasm: Contrary to this supposition, substantial proportions of human cancer specimens have shown overexpression of SIRT1.51–55 SIRT1 aggravates inflammation, inactivates tumor suppressors, and, concomitantly, activates protooncogenes.63,65,71,96 In addition, SIRT1 promotes cancer cell proliferation, invasion, migration, and chemoresistance, conferring survival advantages to cancer cells.51,52,80