ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: The SIRT1 silencing suppressed BCR-ABL-mediated transformation of bone marrow cells and development of a chronic myelogenous leukemia (CML)-like myeloproliferative disease.70 Recently, it has been reported that SIRT1 positively regulates membrane localization and oncogenic activation of Akt via deacetylation.71 The Ras oncoproteins appear to play a role in SIRT1-associated tumorigenesis as well.