In the context of a metastasizing tumor cell, a TF-expressing CTC may expose blood within an uninjured blood vessel to TF (Versteeg et al., 2004; Khorana et al., 2007; Berny-Lang et al., 2011; Otero et al., 2011; Tormoen et al., 2011). This evidence concerns the gene TF and neoplasm.