Immunohistochemically, both carcinomas were negative for oestrogen (ER) and progesterone receptor (PR), cytokeratin 20, alpha-fetoprotein, HepPar-1 and WT-1, and were diffusely positive for HER-2 (Figure 4), p53, E-cadherin, cytokeratin 7, mammaglobin, and carcinoembryonal antigen. Here, TP53 is linked to carcinoma.