Nevertheless, this approach has provided studies linking hypermethylation of certain genes in cells found in oral rinses to not only HNSCC but also moderate-to-severe dysplasias based on EDNRB promoter methylation and to verrucous HNSCC relapse prediction based on methylation status of specific promoter sites in a panel of 5 genes [45, 47]. The gene discussed is EDNRB; the disease is head and neck squamous cell carcinoma.