While activated Cdk5 is classically known to phosphorylate CRMP-2 (collapse response mediator protein) in neurons and leads to growth cone collapse, a recent report has shown that Cdk5-mediated phosphorylation of PIKE-A (Isoform A of phosphatidylinositol 3-kinase enhancer), a novel pro-oncogenic and antiapoptotic factor that activates AKT and promotes cancer cell growth, induces glioblastoma cell migration and invasion [97, 98]. This evidence concerns the gene CDK5 and glioblastoma.