Noticeably, glucocorticoid receptors (GR) are hyperresponsive in PTSD patients, who demonstrate exaggerated responses to dexamethasone administration (de Kloet, Vermetten, Heijnen et al., 2007; Rohleder, Joksimovic, Wolf, & Kirschbaum, 2004; Yehuda, Halligan, Golier, Grossman, & Bierer, 2004). This evidence concerns the gene NR3C1 and post-traumatic stress disorder.