ANXA5 and head and neck squamous cell carcinoma: To examine whether the GSPs-induced loss of the cell viability and induction of G0/G1 phase arrest in HNSCC cells was associated with the induction of apoptosis, SCC1 and OSC19 cells were treated with GSPs for 48 h and the percentage of apoptotic cells were determined using the Annexin V-conjugated Alexa Fluor-488 (Alexa488) Apoptotic Detection Kit as previously described [26].