PGP and major depressive disorder: In a clinic study of depression [35], a set of SNPs in the ABCB1 gene were reported to predict the response to antidepressant treatment in depressed patients receiving drugs of P-gp substrates, including rs7787082 and rs10248420, which were also identified in the present study (Table 1) and are in strong LD with rs1002205 (Fig. 2).