Finally, as pro-inflammatory cytokine production by adipose tissue is a hallmark of obesity [35], we analysed the production of IL-6 by adipose tissue explants from CAV1+/+ and CAV1−/− mice that had been maintained on a high-fat diet (HFD) or a control diet for 12 weeks. This evidence concerns the gene CAV1 and obesity due to melanocortin 4 receptor deficiency.