CAV1 and obesity due to melanocortin 4 receptor deficiency: Furthermore, CAV1−/− mice are resistant to diet-induced obesity and show a mild lipodystrophy [18], [21], [22], [23], and human mutations in CAV1 are associated with a severe lipodystrophic phenotype [24], suggesting defects in lipid storage, adipogenesis or in adipose tissue homeostasis.