In the present study, we investigated c-Abl activation in a mutant SOD1 transgenic ALS mouse model and in sALS patients, and we demonstrated that the c-Abl inhibitor dasatinib has a protective effect on motor neuron degeneration in G93A-SOD1 transgenic ALS mice (G93A mice). The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.