For example, the precursor of miR-558, which has been previously linked with aggressive neuroblastoma [33], contained 5 indels, and an indel (rs34385807) is located the pre-miRNA sequence of miR-141, which is involved in cancer proliferation [34], [35], [36], [37] and has been shown to target the tumor suppressor PTEN[38]. Here, PTEN is linked to cancer.