Anti-myelin basic protein (MBP)- and anti-myelin oligodendrocyte glycoprotein (MOG)-reactive CD8+ T-cell clones restricted by HLA-E have been generated from MS patients, demonstrating that their expression of CD94 and NKG2A was increased during exacerbation, which may limit their capacity to inhibit autoreactive CD4+ T cells [34]. The gene discussed is HLA-E; the disease is myeloid sarcoma.