SiRNA targeting ACTB has been shown to reduce migration of MCF10A breast epithelial cells in a high throughput siRNA screen [28], and down-regulation of AIB1, an adaptor protein involved in actin reorganization and polymerization, suppressed migration, invasion, proliferation and colony formation in MDA-MB-231 breast cancer cells [29]. The gene discussed is ACTB; the disease is breast carcinoma.