IL1B and gastric non-cardia carcinoma: Xue et al. reported IL1-RN -2 allele was associated with an increased risk of developing gastric carcinoma and even more significantly with noncardia gastric carcinoma or with intestinal-type gastric carcinoma [36], indicated IL1-RN VNTR polymorphism associated with different cancer risk according to the subtypes of gastric cancer and histological types.