Two out of thirty-seven of the acute P. vivax infected patients had 35% FOXP3+ Treg (P = 0.001, compared to P. vivax-infected patients), and 1 out of 17 of the uninfected malaria-exposed controls had an extraordinarily high level (31%) of FOXP3+ Treg (P = 0.001, compared with the uninfected malaria-exposed control group, Fig. 2B). This evidence concerns the gene FOXP3 and malaria.