We previously reported a dual behavior of BLCAP in bladder tumors; we observed down-regulation of BLCAP protein associated with progression (up to 51.2% of invasive tumors had weak or undetectable expression), and overexpression of BLCAP only in a minor percentage of tumors (up to 20% of all cases, irrespective of tumor stage/grade) [13]. This evidence concerns the gene BLCAP and neoplasm.