The results established that rs17782313 polymorphism near MC4R was significantly associated with the increased risk of obesity and similar trends were found among subgroups of Europeans and East Asians, adults and children, studies with high quality, and for each of the five polymorphisms investigated (rs17782313, rs12970134, rs571312, rs17700144, rs4450508). Here, MC4R is linked to obesity due to melanocortin 4 receptor deficiency.