MC4R and obesity due to melanocortin 4 receptor deficiency: The rs17782313 polymorphism near the MC4R gene was found to be associated with obesity among both European adults [odds ratio (OR) = 1.12, 95% confidence interval (CI) = 1.08–1.16, p = 5.2×10−9)] and children (OR = 1.30, 95%CI: 1.20–1.41, p = 8.0×10−11) [7].