Indeed, the initial GWAS with ∼14,000 subjects (Indian Asians and Europeans) [50] and two GWAS in East Asians (∼150,000) [51], [52] have confirmed the significant association between MC4R polymorphism and BMI, although the association with obesity risk were not addressed among these three GWAS. The gene discussed is MC4R; the disease is obesity due to melanocortin 4 receptor deficiency.