These genes were reported to be involved in regulating the conversion of tRal into tRol (Dhrs3), regulating UB branching and kidney development (Ppbp and Bmp7), maintaining CD cell polarity and integrity by regulating cell-cell and cell-substrate interactions (Tns1 and Itga2), regulating cellular responses to stress and modulating tissue repair (Sprr1a, Cpm, Lcn2, and Bmp7), regulating water and solute transport mechanisms, and kidney stone formation (Npr3, Foxa1, Clca4, Slc37a1, and Galns). The gene discussed is LCN2; the disease is nephrolithiasis.