Since the p53-PRO/PRO genotype showed more evidence of association with NTG in the MEEI sample and previous studies have suggested that NTG patients are more likely to develop paracentral visual field defects at an early stage of the disease [4], [6], we examined the association between p53-PRO and early paracentral visual field defects in the overall POAG sample (both the NTG and HT-POAG patients). Here, TP53 is linked to open-angle glaucoma.