The p53-PRO/PRO (proline/proline) genotype and proline allele was associated with NTG overall (p = 0.008 and 0.016 respectively), and nominally with POAG overall (NTG and HT-POAG combined) (p = 0.032 and 0.057 respectively) but not with HT-POAG (p = 0.26) in the MEEI sample (Table 2). Here, TP53 is linked to open-angle glaucoma.