Among the weak association signals there were three with immunological disorder: TNFSF4, LY9 and XKR6. Neurologic disorder was nominally associated with SNPs in IRF5 and LY9, serositis with SNPs in LYN and TYK2, discoid rash with SNPs in IRF5 and TYK2, photosensitivity with SNPs in FCGR2A and TNFSF4, hematologic disorder with the SNP in MSH5, and oral ulcers with the PTPN22 nsSNP. The gene discussed is TYK2; the disease is nervous system disorder.