TGFB1 and thyroid gland carcinoma: It is associated with progression of PTC to poorly differentiated thyroid carcinomas due to increased sensitivity to TGFβ-induced epithelial-mesenchymal transition (EMT) [24] and is also associated with vascular endothelial growth factor (VEGF) overexpression and with a greater risk of metastasis, recurrence and shorter disease free survival [25], [26].