In this view, the discovery of the role served by Stim1, Orai1, and TRPC1 in driving RCC-EPC proliferation and tubulogenesis might be helpful in devising alternative strategies, such as the local administration of siRNA targeting the molecular components of SOCE or the intratumoral delivery of selective SOCE blockers via the polymer implants that have been recently described [30]. Here, ORAI1 is linked to renal cell carcinoma.