Therefore, we sought to unveil the molecular underpinnings of SOCE in RCC-EPCs by first measuring CPA-evoked Ca2+ influx in cells transfected with two different siRNA specifically targeting either Stim1 or Orai1, as confirmed at protein level by the immunoblots shown in the Supplementary Material (Fig. S10). Here, ORAI1 is linked to renal cell carcinoma.