For HLA-A*01∶01, the percentage of epitopes in non-permutated versus permutated sequences appears to be relative stable (normal: 0.82 vs 0.80, cancer: 0.77 vs 0.76), whereas permutated HLA-A*03∶01 sequences have more predicted epitopes than the corresponding non-permutated sequences (normal: 0.94 vs 1.01, cancer: 0.91 vs 0.96). The gene discussed is HLA-A; the disease is cancer.