In this study, we have shown that B-cell lymphoma cells as well as normal germinal-center B cells express BMP mRNA, most frequently BMP7. Strikingly, we observed that all lymphoma cells were resistant to this BMP, whereas their sensitivity to BMP-2, -4 and -6 varied from highly sensitive to completely resistant. This evidence concerns the gene BMP7 and B-cell non-Hodgkin lymphoma.